Optimization of Pregelatinized Taro Boloso-I Starch as a Direct Compression Tablet Excipient

Background. Tablets are still the most preferred means of drug delivery. The search for new and improved direct compression tablet excipients is an area research focus. This because method overcomes drawbacks granulation methods production. It exempts several treatment steps associated with methods. requirements powders to be directly compressible include flowability, low friction tendency, compressibility, fast disintegration capacity. Taro Boloso-I a variety Colocasia esculenta (L. Schott) yielding 67% more than previously reported (Godare) in Ethiopia. study aimed at enhancing flowability while keeping compressibility compactibility pregelatinized starch. Methods. Central composite design was used optimization two factors which were temperature duration pregelatinization against 4 responses. responses angle repose, Hausner’s ratio, Heckel’s yield pressure, breaking force. Results Discussions. An increase resulted decrease both repose Hausner ratio that time decreased as well. Heckel pressure observed increasing levels time. starch prepared by heating 15% slurry 66.22°C 20 min showed desired flow property compressibility. Conclusions. Pregelatinized could regarded potential excipient terms compactibility. PGTBIS perform better filler binder tablets Starch 1500®